VP, Translational Science (Nonclinical) Development
$285,000–$380,000 year
On-siteBerkeley Heights, New Jersey, United States
Job Summary
Provide scientific leadership across drug discovery, translational research, and nonclinical development to ensure seamless progression from target identification through IND-enabling studies. Oversee translational strategy and GLP/non-GLP development activities to advance programs from target validation through clinical development and life-cycle management. Guide target validation, pharmacology, and proof-of-concept studies for small molecules, biologics, and vaccines while designing integrated discovery-to-development strategies. Lead biomarker strategies supporting pharmacodynamic assessments and patient selection, collaborating with Clinical Development to inform dose selection and regulatory filings. Serve as the Nonclinical executive sponsor on cross-functional program teams, managing CROs and overseeing adverse event reporting. Own Nonclinical content for regulatory submissions and engage directly with global health authorities. Contribute to due diligence evaluations for in-licensing and M&A activities, support intellectual property development, and publish findings. This role requires a PhD or equivalent doctoral degree with 15+ years of experience in pharmaceutical R&D, including 5+ years in leadership. Salary ranges from $285,000 to $380,000 USD; Tonix does not offer sponsorship.
Required Qualifications
- PhD, PharmD, DVM, MD, or equivalent doctoral degree in pharmacology, toxicology, neuroscience, or a related discipline
- DABT certification
- Minimum 15 years of progressive experience in pharmaceutical or biotechnology research and development
- Experience including drug discovery, translational science, and nonclinical development
- 5+ years in leadership or executive role
- Demonstrated success leading programs from target identification and validation through candidate selection, IND-enabling studies, and clinical development
- Significant experience developing translational strategies that connect disease biology, pharmacology, biomarkers, and clinical development
- Experience leading multidisciplinary research, translational, and nonclinical organizations
- Proven ability to integrate pharmacology, toxicology, DMPK, biomarkers, and regulatory strategy into cohesive development plans
- Excellent written and verbal communication skills
- Capability to influence executive teams and external stakeholders
- Experience supporting regulatory interactions including Pre-IND, IND, End-of-Phase, and global health authority meetings
- Experience managing internal teams and external vendors (CROs, consultants) in a matrixed, cross-functional environment
- Broad expertise in drug discovery, translational medicine, and nonclinical development
- Strong understanding of pharmacology, toxicology, DMPK, and biomarker development
- Experience integrating discovery biology with regulatory nonclinical development
- Strategic portfolio leadership and program prioritization
- Scientific leadership in cross-functional matrix organizations
- Strong regulatory knowledge supporting IND, CTA, NDA, and BLA submissions
- Ability to travel to internal sites and other business needs +20%
- Track record of strategic portfolio leadership, due diligence, and scientific evaluation of external assets
Desired Qualifications
- Prefer exposure to pharmacovigilance/safety risk management in clinical development
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