Sr. Principal Scientist, Pharmacometrics
$156,900–$214,000 year
On-site · San Diego, California, United States
Job Summary
The Sr. Principal Scientist, Pharmacometrics leads PK/PD modeling and simulation efforts to guide clinical development of Neurocrine’s programs. Provides strategic PK/PD methodology expertise, conducts or oversees population PK, PK/PD, and exposure–response analyses to support dose selection, trial design, and regulatory submissions, and oversees M&S work by external CROs. Contributes to the Clinical Pharmacology and Pharmacometrics Development Plan, communicates findings to cross-functional stakeholders, and prepares posters/publications for conferences. Requires advanced degrees with 5+ years post-PhD/PharmD (or MS with 8+ years) in PK/PK–PD modeling and simulation, proficiency with NONMEM, R, WinNonlin, and strong leadership, communication, and project-management skills. The role supports regulatory readiness and interacts with internal decision-making boards and regulatory documents. Base salary range is $156,900.00-$214,000.00 per year, plus a target 30% annual bonus and equity long-term incentives. Benefits include retirement plan with company match and comprehensive health coverage. Location: San Diego, CA, USA.
Required Qualifications
- PhD, PharmD, or equivalent preferred in Pharmacokinetics, Pharmaceutical Sciences, Pharmacology, Chemistry, Biochemistry, or related field with a specific focus on PK and PK/PD modeling and simulation and 5+ years of drug development experience post PhD/PharmD OR MS and 8+ years of Pharmaceutical/Biotech industry experience
- Expert knowledge in conduct and/or oversight of early and late-stage Modeling and Simulation activities
- In depth knowledge of all stages of clinical drug development, including the preparation of components of the Clinical Pharmacology sections of Regulatory submissions for IND- and NDA-stage projects
- Proficient with the use of PK and PK/PD Modeling software tools including NONMEM, R and WinNonlin
- Significant expertise in preparing NDA/MAA summaries of population modeling analyses would be highly beneficial
- Strong communications, problem-solving, analytical thinking, influencing skills
- Good leadership, mentoring skills and abilities typically leads lower levels and/or indirect teams
- Ability to meet multiple deadlines across a variety of projects/programs, with a high degree of accuracy and efficiency
- Excellent project management, strong project leadership skills
- Ability to work in a cross functional team and matrix environment
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