Snr Scientist II / Principal Scientist, In Vivo Biology & Translational Science
On-siteLondon, England, United Kingdom
Job Summary
Lead in vivo pharmacology strategy for Relation's discovery programmes, proposing study designs to support go/no-go decisions and milestone planning across multiple concurrent projects. Drive execution, monitoring, and interpretation of in vivo pharmacology studies covering target engagement, PK/PD, and disease-relevant efficacy endpoints. Own end-to-end CRO relationships for outsourced work packages, managing vendor selection, SOW setup, in-life liaison, data review, and reporting. Commission in vivo-relevant in vitro and ex vivo assays to inform study decisions and translate biology data into actionable insights for cross-functional stakeholders. Maintain rigorous documentation standards across outsourced study packages, including ELN, protocol authoring, and study reporting.
Required Qualifications
- A PhD in Biology, Pharmacology, Biochemistry, or a related scientific discipline or equivalent experience in industrial drug discovery
- Deep expertise in mammalian in vivo study design across target engagement, PK/PD, and efficacy endpoints
- Scientific judgement to define the right experiments to drive project decisions
- Sound knowledge of 3Rs principles
- Proven record of delivering through CRO partnerships to quality and timeline
- Experience commissioning or interpreting in vitro and ex vivo assays in support of in vivo programmes
- Experience across multiple stages of drug discovery (target ID through candidate selection)
- Experience across more than one disease area or physiological system
- Scientifically rigorous and analytically critical mindset
- Ability to interrogate data, challenge assumptions, and deliver across a broad and fast-moving project portfolio
- Exceptional communication and stakeholder management skills
- Ability to distil complex biology into clear project-level insights
- Ability to influence cross-functional decisions
- Comfortable working in a matrixed environment
- Ability to balance multiple stakeholders
- Ability to contribute effectively across teams
- Ability to take ownership of work
- Proactive approach to seeking opportunities to contribute
- Ability to enable others to do their best work
- Ability to communicate openly and directly
- Ability to give and receive feedback constructively
- Ability to handle challenging conversations with respect
- Ability to actively seek out diverse perspectives
- Ability to build strong working relationships
- Ability to contribute to shared goals across teams
- Ability to embrace challenges with openness and resilience
- Ability to set high standards for yourself
- Ability to strive to deliver meaningful outcomes
Desired Qualifications
- Bonus experience: experience working across different drug discovery modalities, including small molecules and/or biologics
- Bonus experience: experience in a TechBio or AI-driven discovery environment
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