Senior Scientist - Principal Scientist, Computational Chemistry
On-site · Boston, Massachusetts, United States
Job Summary
Senior Computational Chemist to lead physics-based simulations and ML workflows for small molecule drug discovery; act as a core strategic partner to medicinal chemists and biologists, focusing on compound design and tool development to impact discovery pipeline; responsibilities include integrating physics-based simulations with ML predictions, developing actionable hypotheses, and deploying workflows to optimize Design-Make-Test-Analyze cycles; requires PhD and 1-3+ years biotech/pharma experience, expertise in structure-based drug discovery, docking, FEP, QM, and proficiency with Linux, Python, RDKit, and related tools.
Required Qualifications
- Ph.D. in Computational Chemistry, Biophysics, or a related field
- 1-3+ years of experience in a biotech or pharma setting performing computational support for small molecule drug discovery
- Advanced knowledge of physics-based and ML computational chemistry packages
- Exceptional ability to communicate the "why" behind a design to a diverse scientific audience
- Design experience with medicinal chemistry teams to design synthesizable compounds
- Proven track record for innovation in structure-based small molecule drug discovery including developing and validating new workflows
Apply with one swipe on Sorce. We auto-fill applications and apply on your behalf — no cover letters, no 40-minute forms.
Hiring someone like this?
Get your role in front of qualified candidates on Sorce.