Senior Scientist / Matrix Lead Brain-Shuttle (m/f/d)
On-sitePenzberg, Bavaria, Germany
Job Summary
Lead cross-functional matrix teams in defining cellular assay strategies for neuroscience projects and overseeing data analysis for mode-of-action elucidations and in vitro lead selection. Conceptually develop and set up novel functional cellular assays employing flow cytometry and advanced fluorescence microscopy to evaluate CNS target engagement, pharmacodynamic activity, and mechanism of action. Provide scientific leadership in developing translational human cellular model systems to characterize blood brain barrier transport and support the discovery of next-generation CNS targeted biologics using Brainshuttle delivery technologies.
Required Qualifications
- PhD in biology with a focus in neuroscience, or another relevant scientific discipline
- Extensive industrial experience in large-molecule and gene therapy drug discovery, with a focus on a neuroscience-relevant portfolio
- Demonstrated ability to lead and inspire highly engaged matrix teams, ideally as a project leader in drug discovery projects
- Solid experience in assay readout technologies such as flow cytometry, live-cell imaging (such as Incucyte) and advanced fluorescence microscopy (confocal, super-resolution, FLIM, smFISH, and high-content imaging)
- Strong background in cell biology and neuroscience
- Deep understanding of blood brain barrier biology and biologics delivery to the central nervous system
- Recognized for your scientific contributions to CNS biologics discovery, blood brain barrier transport, or translational neuroscience
- Deep expertise in Brainshuttle technologies or related approaches for receptor mediated transport across the blood brain barrier, including receptor mediated transcytosis, CNS pharmacology, and translational strategies for brain delivery of biologics
- Proven scientific excellence demonstrated through significant scientific contributions, patents, or publications in leading journals within your field
- Excellent written and verbal communication skills
Desired Qualifications
- Experience in developing and applying translational in vitro model systems to evaluate brain delivery, CNS exposure, target engagement, and pharmacological activity
- A keen interest in working with digital and computational approaches for multiparameter data analysis in (semi-) automated workflows
- Experience with high-throughput screening platforms and large data analysis
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