Senior Scientist, Materials Development
$70,200,000–$80,080,000 year
On-siteGroton, Connecticut, United States
Job Summary
Conduct advanced solid-state characterization of large bRo5 molecules and apply novel crystallization techniques to recrystallize these compounds. Support multidisciplinary project teams by defining and implementing screening activities for polymorphs, salts, and co-crystals, while collaborating with Medicinal Chemistry and Formulation to select solid forms for clinical studies. Solve scientific problems using contemporary experimental techniques and contribute to developing new scientific approaches within the Materials Science organization. Ensure accurate entries in the electronic laboratory notebook system. This full-time role in Groton, CT requires a Master's or PhD with experience in pharmaceutical solid-state characterization and mathematical modeling. Candidates must possess strong data analysis skills and the ability to work independently. The position includes standard benefits, with potential weekend or holiday work based on business needs.
Required Qualifications
- Master's Degree (MS) with 2+ years of experience or a PhD in pharmaceutical science, chemistry, chemical engineering, or related field
- Experience in pharmaceutical solid state characterization techniques (such as x-ray powder diffraction, polarized light microscopy, differential scanning calorimetry, thermogravimetric analysis, spectroscopy, etc.)
- Strong data analysis and interpretation skills
- Experience and understanding of infrared spectroscopy (FTIR, NIR, FT-Raman) and/or SSNMR
- Experience with solving Materials Science problems related to large molecules, e.g., solid state chemistry and particle characterization using experimental approaches and team collaboration
- Experience with amorphous solid dispersion strategies and ability to develop innovative solid form screening strategies
- Understanding of physical, analytical, and organic chemistry
- Good organizational skills, the ability to work independently, and excellent oral and written communication skills
- Experience in mathematical modeling
- May be requested to work on weekends, overtime, and holidays based on business needs
Desired Qualifications
- deep expertise in non-traditional solid-form strategies for beyond Rule-of-5 (bRo5) molecules, including PROTACs, RIPTACs, and molecular glues
- Support the design of advanced solid form screening approaches, amorphous solid dispersion (ASD) formulations, predictive mathematical models
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