Senior Scientist I, Microfluidics
$126,000–$159,500 year
On-siteBoston, Massachusetts, United States
Job Summary
Collaborate with molecular biology scientists to define vector designs, transfection strategies, and assay-readiness criteria for engineered antibody and protein variant libraries. Establish workflows for transfecting, expanding, and qualifying library cell populations while leading the development of biochemical and cell-based droplet-compatible assays for high-throughput screening. Partner with microfluidics engineers to integrate novel assays into robust screening workflows and optimize performance through systematic evaluation of biological and technical parameters. Analyze experimental data to guide platform development and troubleshoot challenges to improve scalability and reproducibility. Document workflows, communicate findings across cross-functional teams, and contribute to SOP development. This role sits at the intersection of molecular biology, cell biology, and microfluidics within Ampersand's flagship Pioneering organization focused on programmed medicines.
Required Qualifications
- PhD in Cell Biology, Immunology, Molecular Biology, Bioengineering, Biomedical Engineering, Biochemistry, Biophysics, or a related field; or MS with substantial relevant industry experience
- Strong hands-on experience with mammalian cell culture, cell handling, transfection workflows, cell selection, and cell-based assay execution
- Demonstrated experience leading the development and optimization of biological assays, preferably protein-based, cell-based or high-throughput screening assays
- Working knowledge of antibody biology, recombinant protein engineering, or antibody discovery workflows
- Ability to design experiments, troubleshoot complex biological systems, interpret quantitative data, and make clear recommendations based on results
- Experience with fluorescence-based detection platforms such as flow cytometry, FACS, microscopy, plate readers, or related systems
- Strong analytical and problem-solving skills with experience interpreting complex biological datasets
- Excellent written and verbal communication skills, with the ability to work effectively across biology, molecular biology, engineering, and platform teams
- Enthusiasm for working in a fast-paced, early-stage biotech environment, including regular collaboration with colleagues across US and European time zones
Desired Qualifications
- Experience developing engineered mammalian cell pools, stable cell lines, reporter cell lines, or functional cell-based screening systems
- Experience with antibody engineering, antibody discovery, directed evolution, display technologies, recombinant protein library screening, or pooled cell-library workflows
- Experience developing functional or cell-based assays for monoclonal antibody discovery
- Exposure to cell-free protein synthesis or related in-vitro expression systems
- Exposure to droplet microfluidics, single-cell screening, microfluidic sorting, or other high-throughput screening platforms
- Familiarity with next generation sequencing-enabled antibody screening workflows
Hiring someone like this?
Get your role in front of qualified candidates on Sorce.