Senior Scientist, Fermentation - IR&D, Product Development
$120,000–$150,000 year
On-siteBaltimore, Maryland, United States
Job Summary
Lead platform fit assessment for novel vectors and optimize upstream fermentation conditions. Execute clone selection using DASGIP and Eppendorf BioFlo systems to identify candidates for RCB and GMP MCB generation. Perform strain selection across E. coli hosts to ensure plasmid stability, integrity, and high yield. Evaluate novel plasmid vectors for AAV/lentiviral production via shake-flask transfection studies and conduct high-throughput screening using the ambr15 48-bioreactor system. Tech transfer clone-specific fermentation processes to Process Development and GMP manufacturing. Drive innovation by improving strain selection, fermentation processes, media, and lysis strategies. Maintain plasmid inventory, oversee fermentation lab operations, and support critical equipment ownership. Troubleshoot technical challenges while collaborating cross-functionally and mentoring junior team members.
Required Qualifications
- PhD degree with 4+ years of upstream process development/R&D
- Master's degree with 8+ years of upstream process development/R&D
- BA/BS with 10+ years of upstream process development/R&D
- Education in a biological, scientific, or engineering discipline (biology, biochemistry, chemical engineering, or equivalent)
- Experience with a wide array of E. coli strains including Dh5, DH10b, NEB, Stbl
- Excellent problem-solving skills
- Excellent written/verbal communication skills
- Strong interpersonal skills and ability to work effectively within a team
- Ability to execute detailed experimental plans
- Ability to record procedures
- Ability to analyze data
- Ability to present results
- Proficiency in MS Office, specifically Excel and Word
- Proficiency in programs for laboratory equipment
- Ability to sit at a desk or computer for periods of time to prepare documentation, reports, and data analyses
- Ability to work in a laboratory environment for extended periods, including standing, walking, or sitting
- Manual dexterity to safely and accurately handle laboratory instruments, pipettes, chromatography equipment, and various tubing and fittings
- Occasional lifting of containers or lab equipment weighing up to 30 pounds
- Good vision and hand-eye coordination for detailed work
- Use of personal protective equipment (PPE) including lab coats, gloves, safety goggles, and, when required, respiratory protection
- 100% Onsite in Baltimore, MD - BioPark
- Shift: Monday - Friday 8AM - 5PM
Desired Qualifications
- Experience with mammalian cell types including HEK293, CHO, and others
- Scale-up of fermentation or cell-culture processes to 50L+ bioreactor scale
- Experience with preparation of regulatory documents
- Experience with various cell lines for recombinant protein and gene therapy vector expression, process development, and/or bioprocess manufacturing
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