Senior Scientist, Discovery Biology
$131,590–$159,454 year
On-siteSan Diego, California, United States
Job Summary
Formulate mechanistic hypotheses for drug discovery projects and design experiments to test them. Find, establish, and execute assays to understand compound mechanisms of action, while developing new projects based on literature and existing data sets. Utilize disease models to design target validation studies and relevant assays supporting SAR. Collaborate with colleagues in informatics and translational research to generate testable hypotheses that validate novel targets and solidify patient selection. Accurately maintain written reports and present results in an organized and timely manner. Communicate effectively to foster teamwork and contribute to project strategy discussions. This role is a primarily bench-facing cancer biology research position within the Protein Homeostasis Thematic Research Center at Bristol Myers Squibb in San Diego, CA.
Required Qualifications
- Bachelor's Degree
- 7+ years of academic and / or industry experience
- Master's Degree
- 5+ years of academic and / or industry experience
- Ph.D. or equivalent advanced degree in the Life Sciences
- Strong molecular and cell biology skillsets
- Excellent capabilities in critical thinking and problem solving
- Ability to independently design and efficiently execute experiments in the lab
- Capable of deliver high quality data in a timely manner
- Cell culture, plate-based assays (eg CTG, annexin V)
- CRISPR
- RNAi
- cloning
- Lentiviral expression
- qPCR
- western blotting
- FACS
- Immunofluorescence
- live cell imaging
- Windows
- MS Office
- graphing software (eg PRISM)
- Capable of leading yet willing to support teams
- Ability to work in a fast-paced dynamic team environment
- flexibility to adapt to changes with a positive attitude
- independently collaborate across teams
- excellent communication skills, both written and verbal
- strong interpersonal skills
- 100% of shifts onsite at your assigned facility
Desired Qualifications
- Ph.D. degree in cancer biology or related field
- 3+ years of relevant academic or industry research experience in cancer biology, oncology target validation and/or drug discovery
- In-depth knowledge of molecular drivers of cancer
- Experience with preclinical models of solid tumors (2D and 3D spheroids and organoids, and cancer stem cells)
- Experience with CRISPR based technologies and cloning to interrogate targets and biological pathways
- Excellent oral and written communication skills, as well as the ability to effectively present scientific data and concepts to international standards
- Experience with targeted protein degradation technologies and molecular glue approaches
- A proven track record in the field of cancer biology/genetics, as evidenced by publication record
- Strong commitment to quality
- demonstrate adaptability
- Ability to effectively present scientific results to multidisciplinary teams
- foster teamwork and contribute to project strategy discussions
- willingness to learn and adapt to any direction a project may take them
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