Senior/Principal Scientist, Computational Neuroscience, Computational Sciences Center of Excellence
$130,800–$242,800 year
HybridSouth San Francisco, California, United States
Job Summary
Develop and execute Genentech/Roche's Foundational Data and Models strategy in Computational Neuroscience to deliver new treatments for neurodegenerative and neuroinflammatory diseases. Analyze and integrate human genetic, single-cell atlases, and perturbation data to derive novel pathobiological insights. Mine large datasets using LLMs, advanced automation, and AI agents to accelerate the Neuroscience portfolio. Nominate new entries to the Target Assessment Portfolio and identify biomarkers for existing therapeutic programs. Serve as computational lead on pipeline programs, supporting target validation, mechanism of action, safety, and biomarker studies. Onsite presence at the South San Francisco campus is expected for at least three days per week.
Required Qualifications
- PhD or equivalent with in-depth training in a relevant field
- deep understanding of both biological pathways relevant to neurodegeneration/neuroimmunology
- computational methods to study these pathways
- Senior Scientist level
- successful postdoctoral research or ≥3 years equivalent experience after PhD
- Principal Scientist level
- deep experience in Perturb-seq and related CRISPR screening
- Patient tissue or CSF/PBMC atlases
- Use of human genetics to prioritize drug targets
- Familiarity with AI approaches and AI agents to enable scientific insights
- A track record of impactful scientific achievement
- co-first/lead as well as contributing author publications
- Excellent communication skills
- evidence of success in complex, multidisciplinary environments
- Onsite presence, on our South San Francisco campus, is expected for at least 3 days a week
- Relocation benefits will be available for this posting
Desired Qualifications
- Master's degree preferred
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