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Revolution MedicinesPosted 2 months ago

Senior Machine Learning Scientist I, Drug Discovery Analytics

$229,000–$269,000 year

On-siteRedwood City, California, United States

Full TimeSenior LevelDoctorate Or Professional DegreeSmall

Job Summary

Senior Machine Learning Scientist I to accelerate drug discovery at Revolution Medicines. Develop predictive models to predict compound activity, selectivity, and developability; create predictive frameworks for ADME/Tox and phenotypic outcomes; apply deep learning, graph neural networks, and ensemble methods; collaborate with medicinal chemists and biologists to support target discovery, lead optimization, and translational research; integrate models into discovery pipelines and work with data/ML engineers to deploy solutions. The role emphasizes cross-functional collaboration across chemistry and biology, handling heterogeneous datasets (chemical structures, screening data, molecular simulations), and advancing data-driven discovery through modeling, validation, and deployment. Preferred skills include cheminformatics tools (RDKit, OpenEye), multi-omics analysis, cloud computing, and MLOps for scalable deployment.

Required Qualifications

  • PhD in machine learning, computational biology, computational chemistry, computer science, statistics, or a related quantitative field
  • 6–10 years of experience applying machine learning or advanced analytics to scientific datasets
  • Python and scientific computing libraries (NumPy, Pandas, SciPy)
  • Machine learning frameworks (PyTorch, TensorFlow, scikit-learn)
  • Model development, validation, and evaluation methods
  • Data visualization and exploratory analysis
  • Experience working with noisy and incomplete experimental datasets

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