Senior Director, Functional Genomics & Organoid Systems Biology

Define and execute the long-term scientific strategy for functional screening and target discovery using patient-derived organoid models. Oversee the design, execution, and interpretation of large-scale CRISPR screening campaigns, including knockout, activation, interference, and pooled screening approaches. Lead drug screening efforts across diverse PDO models to identify therapeutic sensitivities, resistance mechanisms, and rational drug combinations. Drive development of next-generation functional assays incorporating co-culture systems, immune components, and emerging technologies. Establish rigorous experimental standards, quality systems, and reproducible workflows across the screening platform. Partner closely with computational biology and data science teams to prioritize hypotheses arising from real-world patient data. Build, lead, and mentor a high-performing team of scientists, research associates, and laboratory personnel. Manage departmental budgets, resource allocation, and strategic planning.