Senior Director, DMPK
$230,000–$288,000 year
On-site · San Diego, California, United States
Job Summary
Senior Director, DMPK based in San Diego leads the Drug Metabolism and Pharmacokinetics function across discovery and development. Provides strategic leadership for DMPK strategy, collaborates with chemists, biologists, and toxicologists to advance candidates into the clinic, and partners with Clinical Pharmacology and CMC teams to address drug metabolism and drug-drug interaction issues during both early and late-stage development. Responsible for preclinical PK assessments and regulatory submissions (INDs and NDAs), cross-functional program leadership, and development of teams and training. The role emphasizes cross-functional collaboration, continuous improvement, and sound scientific leadership to support IND- and NDA-enabling activities and regulatory documentation. The position is based at Crinetics’ San Diego headquarters, with travel as needed, and offers a competitive salary and comprehensive benefits.
Required Qualifications
- PhD in a relevant discipline with 13+ years of experience in pharmaceutical or life sciences industry
- Applicants with BS or MS degrees may apply, but must demonstrate a minimum of 15+ years of significant and relevant experience
- Minimum supervisory experience of 10+ years
- Excellent verbal, written, and interpersonal communication skills
- Experience in small to mid-sized companies with wide-ranging related responsibilities
- Demonstrated leadership and management skills with a track record of cross-functional collaboration
- Ability to recruit scientists and build teams to support DMPK strategy
- Experience addressing ADME liabilities across drug discovery and development programs
- Ability to interact with chemists, biologists, toxicologists, clinical pharmacology, and CMC teams
- Experience contributing to regulatory submissions (INDs, NDAs) and regulatory responses
- Strategic leadership for DMPK, development of testing strategies and leadership of DMPK programs
- Comfort with traveler requirements (Travel up to a defined percentage) and work at a headquarters setting
- Strong problem-solving, risk assessment, and option management skills
- Ability to influence cross-functional teams and drive project milestones
- Familiarity with preclinical pharmacokinetic assessment from screening to IND/NDA enabling activities
- Proven track record of delivering scientifically rigorous contributions to drug development pipelines
- Leadership in establishing new technologies and methods to improve scientific impact and operational efficiency
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