Senior Associate Scientist – Plate-Based Analytical Assays – Transitional and Early Development
HybridIndianapolis, Indiana, United States
Job Summary
Design, execute, and optimize research-stage plate-based analytical assays including receptor blocking ELISAs, AC-SINS, and PEG precipitation to screen hit monoclonal antibodies and complex biomolecules. Develop robust quantitative ELISAs for lead candidates, ensuring methods meet early robustness criteria for seamless technology transfer to Analytical Development. Proactively source critical tool reagents, analyze large datasets using statistical software, and document all work in electronic lab notebooks. Interface daily with Discovery and Analytical Development teams to align assay strategies with project milestones while evaluating new automation strategies to improve screening efficiency. This laboratory-based role bridges early discovery and clinical development for Elanco's biotherapeutics pipeline, supporting the company's mission to prevent and treat disease in farm animals and pets.
Required Qualifications
- B.S. or M.S. in Immunology, Biochemistry, Molecular Biology, Cell Biology, or a closely related scientific discipline
- B.S. with 4+ years, or M.S. with 2+ years of relevant biopharmaceutical industry experience focusing on assay development and/or early research screening
- Extensive, hands-on expertise in developing, optimizing, and troubleshooting ligand-binding assays (especially ELISAs)
- Demonstrated ability to design and evaluate tool reagents for novel assay development
- Strong analytical problem-solving skills with the ability to learn quickly and assimilate new laboratory techniques
- Excellent written and verbal communication skills, with a track record of effective collaboration in a matrixed team environment
- Minimal travel
- Hybrid work environment
Desired Qualifications
- Direct experience with biophysical/colloidal stability screening assays such as AC-SINS and PEG precipitation assays
- Understanding of the analytical requirements for transitioning early research assays into validate-able methods for late-stage Analytical Development and Quality Control
- Experience with automated liquid handlers or high-throughput plate reading platforms to scale early screening efforts
- Strong background in protein biochemistry and structural understanding of monoclonal antibodies (mAbs) and multi-specific biologics
- Experience utilizing Design of Experiments (DoE) for assay optimization
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