Scientist - Yen Lab/TGEn Group (Hematopoietic Stem Cell, Genome Editing)
$86,320–$154,960 year
On-siteMemphis, Tennessee, United States
Job Summary
Perform studies to develop genome editing strategies for human hematopoietic stem cells (HSC). Design and execute IND-enabling experiments to characterize pharmacology of a genome-edited HSC product to treat sickle cell disease. Assess efficacy, safety, and potency in in vitro and xenotransplantation assays; employ multicolor flow cytometry (FACS) to sort hematopoietic populations; develop methods including RT-PCR, ddPCR, next-generation sequencing, and single-cell sequencing; prepare NGS libraries and analyze editing outcomes (on-target/off-target); evaluate scale-up and closed-system processes for reproducibility; explore delivery strategies; draft documentation (protocols, batch records, reports) to transfer processes to GMP facilities; collaborate with multidisciplinary teams; maintain attendance and perform related duties as assigned.
Required Qualifications
- Bachelor’s degree in a relevant scientific area is required
- Master’s degree or PhD highly preferred
- Eight (8) years of relevant post-degree work experience required with a Bachelor's degree
- Six (6) years of relevant post-degree work experience required with a Master’s degree
- Three (3) years of relevant post-degree work experience required with a PhD
- Experience leading and supporting research experiments preferred
- Experience in guiding and training other laboratory personnel preferred
Hiring someone like this?
Get your role in front of qualified candidates on Sorce.