Scientist II - Viral Vector
$135,200–$135,200 year
HybridSouth San Francisco, California, United States
Job Summary
Produce, purify, and characterize lentiviral libraries and Adeno-associated virus (AAV) vectors to support research and preclinical studies. Perform viral vector analytics using molecular biology techniques including PCR, qPCR, ddPCR, Western blot, and related assays. Maintain viral vector inventory, sample tracking, and documentation using electronic laboratory notebooks and digital informatics systems. Support engineering, optimization, and development of next-generation viral vectors and emerging viral-based therapeutic modalities. Perform mammalian cell culture, transient plasmid transfection, cloning, and other molecular biology techniques. Participate in CRISPR/Cas9 genome editing experiments for both in vitro and in vivo applications. Operate laboratory instrumentation including flow cytometers to support data collection, analysis, and interpretation. Collaborate with multidisciplinary research teams to advance innovative gene therapy platforms.
Required Qualifications
- MS or PhD in Cell Biology, Molecular Biology, Virology, Biochemistry, Bioengineering, Genetics, or a related scientific discipline
- 5–10 years of laboratory research experience in molecular biology, virology, or gene therapy
- Hands-on experience with lentiviral vector production and/or AAV production
- Strong experience with mammalian cell culture and transient plasmid transfection
- Experience with molecular biology techniques including: PCR
- Experience with molecular biology techniques including: qPCR
- Experience with molecular biology techniques including: ddPCR / dPCR
- Experience with molecular biology techniques including: Western Blot
- Experience with CRISPR/Cas9 genome editing technologies
- Strong organizational, analytical, troubleshooting, and communication skills
Desired Qualifications
- Experience with viral vector engineering and next-generation viral modalities
- Experience operating flow cytometers
- Familiarity with electronic laboratory notebooks (ELN) and digital sample management systems
- Experience with data analysis, computational programming, and bioinformatics tools
- Previous experience supporting gene therapy, viral vector core facilities, or translational research programs
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