Scientist II, Genomic Core
$124,000–$155,000 year
On-siteSouth San Francisco, California, United States
Job Summary
Design, develop, optimize, and execute next-generation sequencing workflows on Illumina platforms (MiSeq, NextSeq, NovaSeq) and 10x Genomics systems to support CRISPR-based perturbation studies, single-cell genomics, and high-throughput discovery. Independently troubleshoot complex technical challenges, prepare and QC libraries for bulk RNA-seq, ATAC, and Multiome applications, and manage instrumentation maintenance and reagent inventory. Partner with Functional Genomics, Automation, and Computational Biology teams to ensure data quality for downstream AI/ML analysis while maintaining accurate records in electronic laboratory notebooks. Present technical updates to cross-functional project teams and evaluate emerging methodologies to expand core capabilities.
Required Qualifications
- Ph.D. in Functional Genomics, Molecular Biology, Genetics, Genomics, or a related discipline with 2+ years of industry experience
- M.S./B.S. with equivalent industry experience
- Extensive hands-on experience operating Illumina sequencing platforms, including MiSeq, NextSeq, and NovaSeq
- Extensive hands-on experience with 10x Genomics workflows: 3', 5', ATAC, Multiome, Flex, etc.
- Strong expertise in next-generation sequencing library preparation, including single-cell RNA-seq, bulk RNA-seq, CRISPR-based sequencing assays, and targeted sequencing workflows
- Demonstrated experience supporting CRISPR-based genomics workflows, including Perturb-seq, pooled CRISPR screens, guide sequencing, or related functional genomics applications
- Demonstrated ability to independently design, optimize, troubleshoot, and execute complex genomics experiments with minimal supervision
- Proven experience developing, validating, and implementing new NGS workflows while driving improvements in data quality, throughput, and reproducibility
- Strong understanding of sequencing quality control methods, library characterization techniques, and experimental troubleshooting
- Experience collaborating with multidisciplinary teams, including molecular biologists, automation engineers, and computational scientists
- Ability to independently prioritize multiple projects while providing scientific and technical leadership within cross-functional teams
- Excellent written and verbal communication skills, including the ability to present technical findings to diverse scientific audiences
- A proactive, collaborative mindset with strong troubleshooting and problem-solving abilities
- Enthusiasm for working in a highly interdisciplinary startup environment
Desired Qualifications
- Experience working in a genomics core facility or high-throughput sequencing laboratory
- Experience developing or supporting automated library preparation workflows
- Experience with additional 10x Genomics applications such as ATAC, Immune Profiling, Multiome, etc.
- Experience with molecular cloning, cell engineering, lentiviral workflows, or other functional genomics techniques
- Basic familiarity with bioinformatics tools, NGS data quality assessment, and sequencing data analysis pipelines
- Experience evaluating and implementing emerging sequencing technologies
- Experience supporting AI/ML-driven biological research through generation of high-quality genomic datasets
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