Scientist II, Complex In Vitro Model
$84,500–$162,000 year
On-siteWorcester, Massachusetts, United States
Worcester, Massachusetts, United StatesOn-siteFull Time$84,500–$162,000 yearMid LevelDoctorate Or Professional DegreeEnterprise
Full TimeMid LevelDoctorate Or Professional DegreeEnterprise
Job Summary
Design and perform biochemical and cellular studies of drug potency and mechanism of action using primary human blood cells, cell lines, and complex in vitro systems such as organoids or organ-on-chip models. Analyze, interpret, and communicate quantitative data while maintaining accurate research records. Conduct oral and written presentations to share findings. Read and apply relevant scientific literature to support experimental design. Leverage automation to increase assay robustness and improve throughput.
Required Qualifications
- BS or MS in Biological science with focus in Immunology, Biochemistry, Molecular Biology, Cell Biology, or a related discipline
- 7+ (BS) or 5+ (MS) years of relevant lab experience
- Proficiency in culturing primary human immune cells, immortalized cell lines, and organ/tissue cultures, including differentiated cells and iPSCs, using standard tissue culture and transwell systems
- Experience developing and applying complex in vitro models, including co-culture and advanced 3D cellular systems, to support discovery programs
- Experience designing experiments to study cell signaling, phosphoproteins, second messenger pathways, cell proliferation, gene reporter assays, and soluble mediator release
- Expertise in ELISA/MSD, alphaLISA, HTRF, PCR, multicolor flow cytometry, high content microscopy, and related methodologies
- Strong background in statistics with proficiency in spreadsheets and curve-fitting software such as Microsoft Excel and GraphPad Prism
- Skilled in leveraging automation to increase assay robustness, improve throughput, and enable miniaturization of experimental workflows
- Demonstrated motivation, strong attention to detail, scientific curiosity, and eagerness to learn novel in vitro pharmacology techniques
- Highly collaborative and able to thrive in a fast-paced, cross-functional, multidisciplinary environment, with strong organizational, communication, and interpersonal skills
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