Scientist II, Cell Line Engineering
$145,000–$165,000 year
On-site · San Mateo, California, United States
Job Summary
Lead cell line engineering as core platform capability to support pipeline discovery and early R&D efforts in a lab-based role reporting to Head of Protein Sciences. Onboard core components for expressing pipeline targets, culture/maintain diverse cell lines (knock-outs, stable overexpression, reporter lines), validate expression via flow/NGS-based methods, generate bulk and single-cell populations via FACS, maintain inventory and documentation, explore target expression biology, and establish workflows and deliverables from request to hand-off. Collaborate with end-user stakeholders to confirm domain expression and sequences, and partner with automation engineers to automate routine workflows to increase throughput. Salary range is $145,000–$165,000 plus bonus, options, and benefits.
Required Qualifications
- PhD in biology-related discipline with minimum 3+ years industry experience, preferably in an environment utilizing cell lines for antibody discovery and engineering
- In depth molecular biology knowledge for plasmid construction and experience selecting expression vectors and promoter types
- Experience culturing various cell types, including adherent, suspension, shaker flask etc.
- Demonstrated hands-on success in using CRISPR/Cas9, transposon, or lentivirus based technologies
- Adept with Fluorescence or magnetic-bead based cell sorting methods, and clonal selection and maintenance
- Prior use of automation for cell culture a plus
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