Research Scientist I/II, Immunology
$113,000–$156,000 year
On-siteSan Diego, California, United States
Job Summary
Design and execute in vitro and ex vivo immunology assays using disease-relevant immune cells, tissues, and whole blood to measure potency, selectivity, and target engagement. Run recurring compound-profiling studies to support medicinal chemistry design-make-test-analyze cycles from hit-to-lead through lead optimization. Apply quantitative pharmacology to analyze concentration-response relationships and maintain accurate electronic laboratory records. Contribute to in vivo immunology studies by selecting readouts, processing samples, and interpreting exposure, PK/PD, and efficacy data with pharmacology colleagues. Support assay transfers to CROs by executing bridging work and troubleshooting technical issues while maintaining a culture of scientific rigor. Collaborate closely with biology, medicinal chemistry, DMPK, and machine learning teams to advance small-molecule drug discovery programs at Iambic Therapeutics.
Required Qualifications
- PhD in immunology or a related field, or another biological discipline with immunology-focused postdoctoral training, plus 0–4 years of relevant experience
- MS with 7+ years / BS with 9+ years of relevant experience
- Strong knowledge of innate and/or adaptive immunology, immune-cell signaling, and disease-relevant mechanisms, with the ability to translate biological questions into well-controlled experiments
- Strong hands-on experience designing and executing in vitro and ex vivo immunology studies using primary human and/or animal immune cells, whole blood, or tissue-based systems
- Proficiency in multiparameter flow cytometry, cytokine/chemokine assays, and complementary functional or molecular readouts
- Ability to develop, troubleshoot, and document robust cell-based assay cascades using appropriate controls, counterscreens, and orthogonal readouts to confirm on-target activity and generate reproducible compound-profiling data
Desired Qualifications
- Experience transferring assays to CROs or automated/HTS platforms
- Experience supporting small-molecule discovery through compound screening or profiling; exposure to hit identification, hit-to-lead, or lead optimization
- Working knowledge of in vivo immunology and pharmacology, including model selection, dosing, endpoints, tissue collection, PK/PD, and pharmacodynamic biomarkers
- Direct hands-on experience with in vivo immunology and pharmacology
- Demonstrated scientific rigor, sound experimental judgment, strong organization and communication, and enthusiasm for a collaborative, bench-focused role
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