Research Associate II/ Senior Research Associate, In Vitro Pharmacology
$95,000–$115,000 year
On-site · South San Francisco, California, United States
Job Summary
Design and execute in vitro pharmacology experiments to characterize CRISPR-based epigenetic therapeutics. Develop and optimize cellular assays to evaluate potency, durability, specificity, and mechanism of action; generate high-quality datasets and apply rigorous analyses to inform program decisions. Partner with cross-functional teams to advance therapeutic programs. Culture, engineer, and characterize mammalian cell lines, primary cells, and iPSC-derived disease models. Perform molecular and cellular analyses (qPCR, RT-qPCR, dPCR, Western blot, ELISA, flow cytometry, immunofluorescence) and sequencing-based assays. Evaluate delivery and activity of gene therapy modalities (viral and non-viral); maintain detailed records and contribute to study reports and regulatory documentation. Stay current with CRISPR, epigenetics, gene therapy, and neuromuscular disease research. Compensation: $95,000 to $115,000 USD annually.
Required Qualifications
- B.S. or M.S. in Molecular Biology, Cell Biology, Genetics, Neuroscience, Biomedical Engineering, or related field
- 3–5+ years of relevant industry experience for Research Associate II
- 5–8+ years of industry experience for Senior Research Associate
- Hands-on experience with CRISPR technologies (CRISPR-Cas9, CRISPRi, CRISPRa) or epigenome editing
- Strong molecular biology skills (nucleic acid extraction, PCR, qPCR, dPCR, cloning, gene expression analysis)
- Mammalian cell culture and cellular assay development experience
- Experience with viral vector systems (AAV, lentivirus)
- Proficiency in flow cytometry, immunofluorescence, microscopy, and protein expression analyses
- Strong data analysis, experimental design, and troubleshooting skills
- Ability to independently execute complex studies and contribute to experimental strategy
- Collaborative approach and motivation for transformative therapies
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