R&D Manager Leadership Development Program
$127,313–$147,099 year
HybridPhiladelphia, Pennsylvania, United States
Job Summary
Lead, design, and optimize research exploring next-generation cell therapies using in-vivo CAR-T. Contribute to project creation by dissecting published literature to find novel solutions. Isolate immune cells from leukopak or blood of healthy donors or patients and execute evaluation of in-vivo CAR virus using in-vitro assays and in-vivo mice models. Perform treatment of solid tumor research requiring cell biology techniques including cell culture, transfection, FACS, and cell-based functional assays. Package and titer engineered viruses to infect immune cells in vitro and in vivo; characterize virus particles with protein and PCR based assays; measure transduction rate using flow and VCN analysis. Generate, manage, evaluate, and maintain critical data in a highly organized manner, including the use of ELN. Deliver results to meet timeline with accountability through presentation to a wide range of audiences of internal group meetings and other forums. This Early Career Leadership Program offers structured rotational exposure, executive mentorship, and real-time business impact across scientific, operational, and corporate functions for a recent PhD graduate with 3-4 years of experience in cell and gene therapy.
Required Qualifications
- Expertise in immunology and/or oncology
- Recent PhD graduate in Immunology or related life sciences discipline
- 3-4 years of experience in the field of cell and gene therapy
- in vivo CAR-T experience
- Extensive experience in immune cell-based analytics and assay development including but not limited to advanced multi-parameter flow-cytometry, immunogenicity assay such as cytotoxicity assay, cytokine release ELISA/MSD multiplex assays
- Experience with lentivirus particle characterization and quantification using molecular (VCN) and flow-based assays
- Experience with solid tumor models and in vivo cell-specific gene delivery
- Deep knowledge of immunology and immunotherapy
- Deep understanding of solid tumor models
- Proficient in advanced gene delivery methods using LVV, VLP or LNP technologies
- Strong experience with lentivirus production, tittering and transduction
- Working molecular biology and cellular biology knowledge in design and evaluation of modified viral vectors
- Strong multitasking, problem-solving and collaborative skills
- Be able to work independently to plan and timely execute research projects
- Applicants must be authorized to work in the United States
- If you are selected for employment, you will be required to complete the Form I-9 process, and your employment eligibility will be verified through E-Verify
Desired Qualifications
- within the last 5 years
- 3-4 years of experience in the field of cell and gene therapy required, in vivo CAR-T experience preferred
- Experience with solid tumor models and in vivo cell-specific gene delivery is a plus
- Deep knowledge of immunology and immunotherapy; a deep understanding of solid tumor models is preferred
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