Principal Scientist, In-vivo CAR-T
On-siteMalvern, Pennsylvania, United States
Job Summary
Lead, design, and execute lentiviral vector process development studies from early to late-stage development, combining hands-on laboratory work with cross-functional collaboration to ensure robust, scalable, and GMP-ready processes. Collaborate with modelling experts to identify opportunities where data science reduces experimental burden, while analyzing results to support process understanding and decision-making. Contribute to scale-up and manufacturing readiness, including technology transfer to internal sites or CMOs, and participate in troubleshooting and continuous process improvement initiatives. Document all experimental work in accordance with GxP and data integrity requirements. This role supports the development of in-vivo CAR-T therapies within Johnson & Johnson's Biotherapeutics R&D team in Malvern, PA.
Required Qualifications
- Ph.D. 2-4 years' experience
- B.S. or M.S. with 6-8 years' experience in an appropriate scientific discipline (Life Sciences or Chemical Engineering)
- Relevant experience in process development of viral vectors and/or LVV formulation development
- Strong hands-on laboratory experience in drug product or viral vector development
- Understanding of process scale-up, technology transfer, and GxP principles
- Ability to manage/collaborate in a matrix environment
- Strong scientific problem-solving and data interpretation skills
- Hands-on, proactive, and detail-oriented approach
- Ability to work effectively in a cross-functional, matrixed environment
- Clear and concise communication skills (written and verbal)
- Ability to manage multiple priorities in a dynamic development environment
- Ph.D.
- 2-4 years' experience
- B.S. or M.S.
- 6-8 years' experience
- appropriate scientific discipline
- Life Sciences
- Chemical Engineering
- process development of viral vectors
- LVV formulation development
- hands-on laboratory experience
- drug product
- viral vector development
- process scale-up
- technology transfer
- GxP principles
- manage/collaborate in a matrix environment
- scientific problem-solving
- data interpretation skills
- Hands-on
- proactive
- detail-oriented approach
- work effectively in a cross-functional, matrixed environment
- Clear and concise communication skills
- written
- verbal
- manage multiple priorities
- dynamic development environment
Desired Qualifications
- Experience with LVV platforms, viral vectors and/or advanced therapies
- Familiarity with process validation (e.g., LCPV) and manufacturing support
- Exposure to both early and late-stage development or commercial readiness activities
- Experience with LVV platforms
- viral vectors
- advanced therapies
- process validation
- LCPV
- manufacturing support
- early and late-stage development
- commercial readiness activities
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