Principal Scientist, Epilepsy Research
$136,461–$212,147 year
On-site · Bar Harbor, Maine, United States
Job Summary
Principal Scientist leading in vivo and ex vivo electrophysiology in epilepsy research, designing and executing seizure-model experiments (mouse models such as kainate, pilocarpine, kindling, Scn1a+/−), performing chronic recordings (EEG/LFP), surgical electrode implantation and long-term telemetry, developing new model systems for drug-resistant/pediatric epilepsies, leading acute and organotypic brain-slice work (patch-clamp/field potential recordings), analyzing pharmacological modulation of neural systems, and guiding preclinical therapeutic development in collaboration with medicinal chemistry and translational teams; includes mentorship of a small team, defining research priorities, presenting at reviews and conferences, and contributing to grant writing and IP generation. Knowledge of IND-enabling studies and regulatory submissions, and a strong track record of independent, rigorous, and reproducible science in CNS pharmacology and epilepsy; expected to contribute to a senior, autonomous research program with competitive compensation and comprehensive benefits.
Required Qualifications
- PhD in Neuroscience, Pharmacology, Physiology, or a closely related discipline
- Minimum 8 years of post-doctoral research experience, with a demonstrated track record in epilepsy or seizure biology
- Expert-level proficiency in in vivo electrophysiology, including EEG recording and analysis in rodent seizure models
- Expert-level proficiency in brain slice preparation and patch-clamp or field potential electrophysiology
- Extensive hands-on experience with rodent models of epilepsy and associated surgical, behavioral, and data analysis workflows
- Direct experience contributing to preclinical therapeutic development programs, including target validation and compound profiling
- Strong publication record in peer-reviewed journals relevant to epilepsy, ion channel biology, or CNS pharmacology
- Demonstrated ability to independently design, execute, and interpret complex experiments and communicate findings clearly
- Experience with genetic mouse models of epilepsy (preferred)
- Familiarity with advanced imaging modalities (preferred)
- Experience with translational biomarker development or clinical EEG interpretation (preferred)
- Prior experience in biotech/pharma or translational research environment (preferred)
- Familiarity with regulatory guidelines for CNS packages (FDA/EMA) (preferred)
- Experience with gene therapy or RNA-based therapeutic modalities (preferred)
- Proficiency in experimental design, data analysis, and interpretation
- Excellent leadership, communication, and interpersonal skills
- Ability to thrive in a fast-paced environment and manage multiple projects
- Knowledge of regulatory guidelines and compliance in industry (preferred)
- Ability to mentor junior scientists and drive team deliverables
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