Principal Scientist, Cell Pharmacology
$160,000–$190,000 year
On-siteCambridge, Massachusetts, United States
Job Summary
Lead development, optimization, and implementation of high-throughput cell-based assays to advance Helicon peptide programs and identify lead candidates across oncology indications. Serve as a subject-matter expert on target engagement and functional assays, providing guidance to cross-functional discovery teams. Manage and mentor a small team executing cell-based assay development and screening, collaborate with biology leads and cross-functional partners to inform SAR and development candidate selection, and drive IND-enabling studies with strategic planning. Lead a new LIMS initiative for biology and ensure data QC uploads for easy access by multiple functions; contribute to data-driven decision making in executive meetings. Mentor junior scientists, champion scientific innovation, and evaluate emerging technologies for internal application. Demonstrated ability to utilize AI tools for day-to-day work is expected; advanced usage is a strong plus. Able to work on-site in Cambridge, MA.
Required Qualifications
- B.S., M.S., or PhD in cancer biology, molecular biology, or related discipline
- 15+ years of industry experience in drug discovery and cellular biology
- proven track record designing and executing complex cell-based assays (e.g., HTRF, AlphaLISA, NanoBRET, HiBiT, MSD)
- significant experience leading high-throughput cellular screens and analyzing multiparametric datasets
- deep expertise in mammalian cell culture, CRISPR/RNAi, western blotting, qPCR, flow cytometry, immunofluorescence, and high-content imaging
- strong data management and documentation skills; experience with Dotmatics or similar platforms
- leadership/mentoring experience; ability to manage a small team
- excellent communication and cross-functional collaboration skills
- ability to work on-site in Cambridge, MA
Desired Qualifications
- 15+ years of industry experience in drug discovery and cellular biology
- leadership/people management experience
- expertise in cell-based assays and high-throughput screening
- experience with AI tools in day-to-day work (strong plus)
- strong communication and cross-functional collaboration skills
- mentoring and technical advising to junior scientists
- experience with LIMS/data management systems and QC processes
- ind-enabling studies and transitioning discovery to development
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