Principal Scientist - Cardiometabolic Disorders
On-siteThousand Oaks, California, United States
Thousand Oaks, California, United StatesOn-siteFull TimeSenior LevelDoctorate Or Professional DegreeEnterprise
Full TimeSenior LevelDoctorate Or Professional DegreeEnterprise
Job Summary
Provide scientific leadership for obesity drug discovery programs from target identification through candidate selection. Develop translational pharmacology strategies to evaluate novel therapeutic mechanisms and optimize candidate molecules. Design, oversee, and interpret in vitro and in vivo pharmacology studies, including efficacy, mechanism-of-action, PK/PD, and biomarker investigations. Lead cross-functional scientific discussions to influence program direction through rigorous data interpretation. Mentor scientists and present findings to senior leadership and external audiences.
Required Qualifications
- Doctorate degree PhD OR PharmD OR MD [and relevant post-doc where applicable]
- 2 years of experience in pharmaceutical, biotechnology, or related drug discovery research
- Master's degree and 5 years of experience in pharmaceutical, biotechnology, or related drug discovery research
- Bachelor's degree and 7 years of experience in pharmaceutical, biotechnology, or related drug discovery research
Desired Qualifications
- PhD in Pharmacology, Physiology, Endocrinology, Cell Biology, Molecular Biology, or a related scientific discipline
- 5+ years of experience in pharmaceutical or biotechnology drug discovery
- Extensive expertise in GPCR biology, pharmacology, and signaling, with a deep understanding of receptor pharmacology, signal transduction, and mechanism-of-action studies
- Demonstrated experience developing, optimizing, and applying GPCR-based in vitro pharmacology assays, including functional signaling assays, ligand-binding assays, receptor internalization, β-arrestin, cAMP, calcium mobilization, and pathway-selective (biased signaling) analyses
- Strong expertise in pharmacological characterization of peptide, antibody, multispecific, or other biologic therapeutics
- Experience designing and interpreting in vivo pharmacology studies to support target validation, mechanism-of-action, and candidate selection
- Demonstrated ability to integrate in vitro pharmacology, in vivo efficacy, PK/PD, biomarker, and human biology data to guide scientific decisions and advance discovery programs
- Proven scientific leadership with the ability to independently develop innovative scientific strategies, solve complex biological problems, and influence multidisciplinary project teams
- Experience mentoring scientists and leading cross-functional collaborations in a fast-paced drug discovery environment
- Excellent written and verbal communication skills with a strong track record of publications, presentations, and scientific contributions
- Demonstrated creativity, scientific curiosity, and a passion for discovering transformative therapies for patients with obesity and related metabolic diseases
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