Principal Research Scientist I, Biologics Screening - Discovery Biotherapeutics
$124,500–$236,500 year
On-site · San Francisco, California, United States
Job Summary
Lead biologics screening programs from exploratory to candidate nomination; supervise 1-2 scientists; develop and apply high-throughput biosensor and cell-based assays; utilize biophysical characterization and epitope binning; collaborate with Oncology and cross-functional teams to drive go/no-go decisions; apply cutting-edge technologies to advance large molecule therapeutics in early discovery through lead identification and optimization. Strong emphasis on protein sciences, antibody discovery, and data-driven decision making.
Required Qualifications
- BS, MS, or PhD with typically 14+ (BS), 12+ (MS), or 6+ (PhD) years of relevant experience
- Experience with biologics, monoclonal antibodies and/or protein therapeutics
- Experience advancing Discovery programs from exploratory to candidate nomination
- Independently develop and execute biosensor and cell-based platforms to evaluate panels of antibody biotherapeutics
- Implement high-throughput epitope binning for large panels of monoclonal antibodies and develop deep knowledge of antibody sequence/function relationships
- Evaluate and integrate biomolecular interaction technologies (e.g., SPR) to guide therapeutic candidate selection recommendations
- Expert in biophysical characterization instrumentation and methodologies such as SEC, MS, HDX-MS, X-ray crystallography, DSF, DLS, etc.
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