Principal Quantitative Pharmacologist (Pharmacometrician)
$150,500–$245,500 year
Remote · United States or Cambridge, Massachusetts, United States
Job Summary
Principal Quantitative Pharmacologist (Pharmacometrician) role focused on prospectively designing and conducting sophisticated PMx analyses to support program development strategies across multiple experiments and clinical trials. Responsibilities include communicating PMx results to development teams, implementing strategic PMx changes to program direction and regulatory interactions, drafting regulatory documents (IBs, briefing books) for pre-IND and HA meetings, delivering study reports and figures for leadership presentations, and mentoring PMx staff. Candidate should bring expertise in PMx concepts (compartmental/translational modelling, exposure–response, nonlinear mixed effects, logistic regression, survival analysis, Bayesian approaches, disease modelling/QSP) and regulatory experience, with proficiency in Excel, R/R-Studio, Phoenix WinNonlin, NLME, NonMem, STAN. Regeneron emphasizes on-site work for many roles and offers inclusive benefits in the US, with salary range $150,500–$245,500 annually for US-based positions.
Required Qualifications
- PhD with 4+ years of relevant industry experience or MS with relevant industry experience
- Understanding of PMx concepts and techniques (compartmental modeling, translational modelling/pharmacology, Exposure-Responses analysis, nonlinear mixed effects modeling)
- Knowledge of advanced PMx methodologies for clinical trials (survival analysis, covariate analyses, missing data strategies)
- Regulatory experience through authoring regulatory briefing books, CTD summaries, HA meetings, and negotiations
- Proficiency with analysis tools (MS Excel, R, R-Studio, Phoenix WinNonlin, NLME, NonMem, STAN)
- Strong written and verbal communication; ability to draft and review regulatory documents and briefing materials
- Willingness to work on-site in the US per policy
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