Principal Product Manager, Real World Evidence Intelligence
$186,000–$233,000 year
On-site · Redwood City, California, United States
Job Summary
Principal Product Manager, Real-World Evidence Intelligence aims to shape and deliver RWE capabilities across clinical development, regulatory, medical, HEOR, market access, and post-approval use cases. You will define the vision and roadmap for RWE products, translate evidence workflows into scalable product requirements, and enable self-service evidence intelligence with modern AI and low-code tooling. Responsibilities include prioritizing capabilities to improve cohort discovery, enrollment feasibility, external comparator readiness, data fitness, provenance, and evidence generation speed, as well as partnering with data providers, vendors, and internal teams to build, buy, or integrate solutions. The role emphasizes working with data from claims, EHR, registries, genomics, PROs, and other sources to turn real-world data into decision-grade insights, driving adoption and measurable outcomes across programs and indications. A strong background in oncology-related RWE, regulatory-grade evidence generation, and experience delivering data products or AI-enabled evidence decision-support capabilities are preferred. The position requires senior leadership, cross-functional collaboration, and the ability to navigate a regulated biotech environment, privacy and governance considerations, and vendor management in pursuit of scalable RWE platforms and capabilities.
Required Qualifications
- 12+ years of experience in Product Management, Data Product Management, RWE Informatics, Life Sciences Data Platforms, Evidence Strategy, Epidemiology, HEOR Analytics, Outcomes Research, or related roles within biotech, pharma, healthcare technology, consulting, data providers, or another regulated environment
- Strong product leadership experience defining vision, shaping strategy, building roadmaps, prioritizing tradeoffs, influencing senior stakeholders, and delivering measurable outcomes
- Deep understanding of how RWE supports clinical development, regulatory strategy, medical strategy, HEOR, market access, safety, and post-approval evidence generation
- Experience translating evidence workflows into scalable product capabilities, user stories, evaluation criteria, and product requirements
- Working knowledge of RWD sources, observational methods, and evidence-grade practices, including claims, EHR, registries, labs, genomics, PROs, cohort definition, confounding, endpoint construction, comparative effectiveness, external comparators, synthetic cohorts, data quality, provenance, reproducibility, privacy, governance, and compliance
- Product judgment to evaluate build, buy, partner, and integration options based on user value, data fitness, vendor maturity, compliance needs, scalability, interoperability, and maintainability
- Strong communication and stakeholder management skills across evidence, clinical, medical, market access, safety, technical, legal, compliance, vendor, and executive audiences
- Advanced degree or equivalent experience in Life Sciences, Public Health, Epidemiology, Health Economics, Outcomes Research, Biostatistics, Biomedical Informatics, Computer Science, Information Systems, Engineering, or a related field
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