Postdoc - Chemistry Innovations for Oligonucleotide Therapeutics (m/f/d)
On-site · Aachen, North Rhine-Westphalia, Germany
Job Summary
Postdoctoral Scientist in Chemistry Innovations for oligonucleotide therapeutics. Operate at the chemistry–biology interface within Grünenthal’s Chemistry, Discovery Biology, and Genetic Medicine groups. Design and synthesize novel siRNA/ASO constructs with advanced backbone modifications; develop targeted conjugates to improve tissue specificity and intracellular trafficking; collaborate with biology-focused scientists to translate chemical innovation into functional delivery solutions; contribute to translational impact and scientific excellence through data interpretation and publications. Embedded in a cross-disciplinary team, you will leverage internal synthesis capabilities for rapid design–make–test cycles, engage with external partners, and advance next-generation delivery modalities in RNA-based therapeutics. Requirements include a Ph.D. in a related field with hands-on oligonucleotide synthesis experience, expertise in phosphoramidite chemistry and bioconjugation, and strong communication skills; programming experience is advantageous. Location: Aachen, Germany; status: temporary, full-time, on-site.
Required Qualifications
- Ph.D. in Organic Chemistry, Chemical Biology, or a related field
- strong hands-on experience in oligonucleotide synthesis
- expertise in phosphoramidite chemistry and design of linkers/conjugates
- background in bioconjugation chemistry and development of siRNA/ASO conjugates
- proficiency in HPLC and mass spectrometry
- fluency in English; programming experience (Python) is a plus
Desired Qualifications
- Ph.D. in Organic Chemistry, Chemical Biology, or a related field
- hands-on experience in oligonucleotide synthesis
- deep expertise in phosphoramidite chemistry
- design of linkers and conjugates at both terminal and internal oligonucleotide positions
- solid background in bioconjugation chemistry, including development of siRNA/ASO conjugates
- proficiency in analytical techniques such as HPLC and mass spectrometry
- strong written and spoken English
- experience with programming (e.g., Python) for oligonucleotide sequence analysis is an advantage
- ability to collaborate across multidisciplinary teams
- ability to work in an international, multicultural environment
Apply with one swipe on Sorce. We auto-fill applications and apply on your behalf — no cover letters, no 40-minute forms.
Hiring someone like this?
Get your role in front of qualified candidates on Sorce.