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Merck Sharp & Dohme Farmaceuticatoday

Director - Pharmacometrics AI Lead

$190,800–$300,300 year

On-site · Rahway, New Jersey, United States or West Point, Pennsylvania, United States

Type
Full Time
Level
Senior Level
Education
Doctorate Or Professional Degree
Company size
Unknown

Job Summary

Director – Pharmacometrics AI Lead responsible for shaping and executing a multi-year transformation to integrate AI/ML into quantitative pharmacology workflows (MIDD). Lead a pharmacometrics team, identify scalable AI/ML use cases to accelerate development timelines, evaluate emerging AI/ML technologies, transition pilots to enterprise-scale solutions, and partner with IT and strategy offices to implement robust AI capabilities. Drive adoption through training and upskilling, foster a culture of innovation, oversee external collaborations (industry, academia, technology providers), and maintain awareness of evolving AI/ML tools and their application to pharmacometric workflows. Requires a Ph.D. with substantial pharmacometrics experience, leadership in applying AI/ML to drug development, and the ability to influence senior stakeholders and guide strategic direction. Proficient in PK/PD, disease modeling, dose–response, trial simulation, MIDD principles, and modern analytics ecosystems; hands-on experience with Python/R/Matlab and ML frameworks; strong communication and strategic thinking to impact portfolio decisions.

Required Qualifications

  • Ph.D. with at least 8 years of experience in pharmaceutical drug development or related field
  • deep hands-on expertise in pharmacometrics (e.g., population PK and PK/PD analyses, model-based meta-analysis, dose–response and exposure–response analyses, disease modeling, trial simulation, optimal study designs)
  • experience applying AI/ML methods in drug development with demonstrated examples (publications, projects)
  • leadership experience in scaling digital solutions from pilot to enterprise deployment
  • strong knowledge of regulatory expectations and the evolving role of AI/ML in clinical development
  • strong communication and stakeholder-management skills
  • ability to collaborate across multidisciplinary teams and external partners
  • experience with AI tools and programming languages (Python/R/Matlab; TensorFlow/PyTorch)
  • ability to craft executive-level narratives and influence senior stakeholders
  • experience with cloud platforms and data architectures
  • ability to initiate and manage external collaborations with academia, industry, and technology providers
  • willingness to participate in enterprise AI/ML efforts and contribute to strategic planning
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$191k – $300k / yr

Director - Pharmacometrics AI Lead · Merck Sharp & Dohme Farmaceutica

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