Director, Chemistry
$145,000–$185,000 year
On-site · San Diego, California, United States
Job Summary
Director, Chemistry will provide scientific and strategic leadership for the design, optimization, and advancement of next-generation oligonucleotide therapeutics, focusing on conjugation chemistry and targeted delivery technologies. Lead cross-functional discovery programs from concept through IND-enabling studies, evaluate emerging modalities such as antibody-oligonucleotide conjugates (AOCs) for expanded extrahepatic delivery, and build high-performing teams. Responsibilities include driving conjugation design and chemical optimization, advancing platform capabilities in bioconjugation and ligand-mediated delivery, leading multidisciplinary teams, guiding candidate selection, collaborating with biology, DMPK, toxicology, translational sciences, and clinical development, presenting findings to executive leadership, and staying current with developments in oligonucleotide therapeutics and delivery technologies.
Required Qualifications
- Ph.D. in Chemistry, Medicinal Chemistry, Pharmaceutical Sciences, or related scientific discipline
- 10+ years of industry experience in oligonucleotide therapeutics, conjugation chemistry, or targeted delivery platforms within biotechnology or pharmaceutical settings
- Demonstrated success advancing therapeutic programs from discovery through IND-enabling studies
- Strong experience with ligand-mediated delivery, receptor targeting, and extrahepatic delivery approaches
- Expertise in bioconjugation technologies and emerging modalities
- Proven leadership experience managing cross-functional scientific teams and complex research programs
- Strong understanding of pharmacology, DMPK, biodistribution, and translational considerations for oligonucleotide therapeutics
- Excellent communication, collaboration, and strategic leadership skills
- ADARx Pharmaceuticals is an EEO employer committed to an exciting, diverse, and enriching work environment.
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