Biotransformation Scientist
On-siteSt. Louis, Missouri, United States
St. Louis, Missouri, United StatesOn-siteFull TimeDoctorate Or Professional DegreeHealthcare TechMedium
Full TimeDoctorate Or Professional DegreeMediumHealthcare Tech
Job Summary
Design and execute laboratory studies to identify enzymatic pathways metabolizing small molecule, peptide, and oligonucleotide therapeutics using contemporary approach methodologies. Elucidate primary drug clearance mechanisms in vitro and establish in vitro-to-in vivo correlations for predicting human half-life. Collaborate with pharmacology and toxicology teams to execute ADME studies, including absorption, distribution, metabolism, and excretion, while developing novel approach methodologies for mechanistic inquiries. Utilize LC-MS/MS and HRMS techniques to quantify metabolites and interpret mass spectrometry data.
Required Qualifications
- PhD in Organic Chemistry, Biochemistry, Analytical Chemistry or related discipline with 2-5 years direct industrial biotransformation experience following Post Doctoral training
- M.Sc. in a discipline previously described with 5-7 years direct industrial biotransformation experience
- Experience conducting in vitro and ex vivo biotransformation assays utilizing LC–MS/MS & HRMS techniques for quantitation and structure elucidation
- Experience, skills, and abilities must include knowledge of contemporary bioanalytical techniques, including wet chemistry separations, liquid chromatography, and mass spectrometric analysis
- Experience, skills, and abilities must include knowledge of contemporary bioanalytical techniques, including wet chemistry separations, liquid chromatography, and mass spectrometric analysis, instrument operation, and data processing
- A working knowledge and awareness of general laboratory procedures
- Good written and oral communication skills
- Ability to adhere to all safety regulations and procedures
- Working command of in vitro kinetic analysis and utilization of contemporary mathematical models to effectively analyze, interpret and/or model drug clearance, predicted half life, and drug-drug interactions
- Ability to perform mass spectrometry data collection, analysis and interpretation experience via LC-MS/MS
- Immunization to Hepatitis B and/or other diseases
Desired Qualifications
- Knowledge of enzyme kinetics desirable
- Ability to incorporate software in the maintenance of databases to collate and catalog records and inventory
- Independence in the laboratory and data work-up phases of research
- Candidates possessing a command of Pharmacokinetic modeling, analysis, interpretation and simulation desirable
Hiring someone like this?
Get your role in front of qualified candidates on Sorce.