Associate Scientist/Scientist I, Protein Science Developability
$88,000–$144,000 year
On-siteCambridge, Massachusetts, United States
Job Summary
Design, optimize, and execute high-throughput protein purification workflows using AKTA chromatography systems across diverse protein classes. Perform mass spectrometry-based analyses to confirm protein identity, assess purity, and characterize post-translational modifications. Develop and validate bioassays for binding, activity, and stability to assess protein function and quality. Partner with automation engineers to integrate workflows into automated workcells and collaborate with computational scientists to support data analysis pipelines. Identify opportunities to improve throughput, yield, and reliability of methods while ensuring data quality and reproducibility.
Required Qualifications
- MS in Biochemistry, Biophysics, Bioengineering, Molecular Biology, or a related field with 4+ years of relevant experience
- PhD in a related discipline with 0-2 years of postdoctoral or industry experience
- Experience operating AKTA chromatography systems for protein purification
- Proficiency across a wide range of chromatographic techniques (e.g. affinity, SEC, HIC, IEX, etc.)
- Ability to develop, optimize, and troubleshoot purification workflows
- Hands-on experience in LC-MS techniques for protein characterization
- Experience with intact mass analysis
- Experience with peptide mapping
- Experience with PTM identification
- Experience with glycosylation profiling
- Exposure to interpretation of complex mass spectral data
- Ability to troubleshoot instrument performance
- Familiarity with assay development, optimization, and data analysis for bioassay techniques
- Experience with ELISA
- Experience with AlphaLisa
- Experience with SPR/BLI
- Experience with functional activity assays
- Strong laboratory data analysis skills
- Experience with digital recordkeeping (e.g., Benchling)
- Collaborative scientific workflows
- Outstanding analytical skills
- Problem-solving skills
- Meticulous attention to data quality and reproducibility
- Effective communication skills
- Eagerness to collaborate within a fast-paced, cross-functional team
Desired Qualifications
- Experience working with laboratory automation platforms
- Experience with high-throughput screening workflows
- Familiarity with additional protein characterization techniques such as CE-SDS, SEC-MALS or DSF
- Experience with data analysis tools (e.g., Python, R, or equivalent)
- Experience with automating data workflows
Hiring someone like this?
Get your role in front of qualified candidates on Sorce.