Associate Scientist, Protein Sciences
$115,000–$125,000 year
On-siteSan Jose, California, United States
Job Summary
Produce and purify novel logic-gated alternative format antibodies using mammalian expression systems, including AKTA and HPLC chromatography. Generate target over-expressing cell lines and develop strategies to express, purify, and analyze proteins for novel tumor targets. Conduct antibody characterization via Octet/Biacore, epitope binning, and functional assays while troubleshooting experimental issues. Mentor lower-level colleagues, analyze data, and maintain accurate laboratory documentation following safety procedures. Contribute to project team meetings and support the development of antigen antibodies for early discovery and validation research.
Required Qualifications
- PhD in biological sciences or a related field, including candidates who are completing or have recently completed their PhD
- MS with 5+ years
- BS with 8+ years of relevant experience in the biopharmaceutical industry or a closely related scientific discipline
- Experience in molecular biology or/and biochemistry
- Experience in gene manipulation
- Experience in subcloning
- Experience in expression vector modifications
- Experience in protein expressions in HEK & CHO cell systems
- Extensive experience in human protein and antibody purification techniques
- Experience in affinity chromatography
- Experience in Mixed mode chromatography
- Experience in Hydrophobic Interaction Chromatography (HIC)
- Experience in Ion Exchange Chromatography (IEX)
- Experience in Size Exclusion Chromatography (SEC)
- Proficiency in operating and troubleshooting modern chromatography hardware and software
- Experience with Cytiva AKTA systems
- Experience with Agilent HPLC and UPLC
Desired Qualifications
- Experience in developing and optimizing recombinant proteins and bi- and multi-specific antibody formats across multiple parameters
- Antibody drug discovery experience for immune oncology in biopharmaceutical industry
- Ability to independently manage projects and deliver results on stringent timelines with high quality
Hiring someone like this?
Get your role in front of qualified candidates on Sorce.