Associate Scientist, Protein Sciences
$115,000–$135,000 year
On-site · South San Francisco, California, United States
Job Summary
Develop parallel purification processes for antibodies, bispecifics and cytokines; collaborate with discovery, protein engineering and pharmacology to provide therapeutic and reagent proteins of appropriate quality for use in in vitro and in vivo studies; develop production and purification strategies for various PROBODY bispecific formats; solving protein purification problems based on scientific principles, current technologies, and personal experience; support the lead selection process by developing various analytical, LC-MS and biophysical methods to characterize novel PROBODY molecules; participate in cross-functional discovery supports and effectively communicates information to appropriate groups and protein sciences staff.
Required Qualifications
- PhD in Biochemistry or Protein Chemistry or related discipline OR MS in Biochemistry with 5+ years of experience in the biotechnology or biopharma industry with increasing responsibility
- Expertise in problem solving the protein purification issues is required
- Expertise in large and small-scale protein purification using AKTA systems, Tecan or Janus liquid handler system is required
- Expertise in protein characterization assays such as concentration, endotoxin measurement, SDS-PAGE, CE-SDS, SEC-HPLC, RP-HPLC, HIC and IEF are required
- Hands-on experience in operating HPLC or UPLC instruments is required
- Experience in developing analytical methods to characterize antibodies, bispecifics and cytokines is required
- Experience in managing the protein purification workflow is required
- Please note that a presentation of a scientific seminar is required during the interview process
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