Associate Scientist I, Formulation Development
$99,750–$110,250 year
HybridSan Diego, California, United States
Job Summary
Conduct formulation stability studies and in-use compatibility studies for mAb and AOC liquid and lyophilized dosage forms. Perform developability assessments of early-stage protein biologics using predictive analytical and biophysical methods. Execute routine laboratory tasks including buffer preparation, inventory management, and instrument maintenance. Specify, purchase, and manage the installation of formulation-related instrumentation. Maintain electronic documentation and prepare technical reports. Present data at regular team and cross-functional meetings. This role supports clinical and commercial formulation development within Avidity's Technical Development and Operations department, focusing on Antibody Oligonucleotide Conjugates for rare muscle diseases.
Required Qualifications
- A bachelor's degree (or master's) in chemistry, biology, pharmaceutical sciences, or a related field
- minimum of 5 years of industrial experience (3 years for a master's degree)
- An understanding of protein physicochemical stability, particularly for common routes of mAb degradation
- Experience in setting up and managing formulation development and in-use compatibility studies
- Hands-on experience with a variety of analytical methods including SEC, IEX, RP-HPLC, CE-SDS, cIEF and subvisible particle analysis
- Experience using a variety of biophysical methods for characterizing and measuring conformational and colloidal stability of protein biologics including differential scanning calorimetry, dynamic and static light scattering techniques
- Ability to multi-task and work in a fast-paced cross-functional matrix environment
- Demonstrated excellent communication (oral and written), teamwork, organizational, interpersonal, and problem-solving skills
Desired Qualifications
- Experience using design of experiment (DOE) approaches
- Familiarity with mass spectrometry (MS) methods used for assessing mAb chemical stability and assessing ADC drug to antibody ratios including intact, reduced, and peptide mapping LC/MS
- Prior experience in lyophilization formulation, cycle development, and analytical testing
- Experience in oligonucleotide chemistry and characterization methods
- Experience working with external CMOs and CROs
Hiring someone like this?
Get your role in front of qualified candidates on Sorce.