Associate Principal Scientist
On-siteBristol, Pennsylvania, United States
Job Summary
Drive and support technical execution of R&D bioconjugation activities, delivering client and internal projects from initial assignment to completion. Perform hands-on chromatographic purifications, membrane filtrations, buffer preparation, and conjugation reaction work-up while developing and optimizing bioanalytical characterization of products. Serve independently as bioconjugation technical lead and subject-matter expert for internal and external communications, including client-facing scoping calls and proposal generation. Lead technical transfer of processes to manufacturing, authoring batch records and protocols per ICH and FDA guidelines, and mentor assigned reports. Coordinate activities with QA/QC for tox and GLP batches and maintain strong technical understanding of bioconjugation advancements.
Required Qualifications
- A PhD in chemistry, bioorganic chemistry, chemical biology or similar
- >7 years industry experience in biotherapeutic conjugate development or bioconjugation
- Demonstrated experience applying and optimizing state-of-the-art bioconjugation or bioorthogonal chemistry techniques to produce conjugates (ADCs, AOCs/ARCs, PDCs, DACs, etc.) at various scales (mg-gram scales)
- Thorough, hands-on experience with small-scale and preparative chromatography systems (AKTA Pilot, AKTA Ready, AKTA Explorer, etc.) for purification of biomacromolecules (antibodies, fusion proteins, carrier proteins, viruses, viral vectors, or other biologics)
- Expertise in normal flow filtrations and tangential flow filtrations (TFF or UF/DF)
- Knowledge of strategies for the optimization of bioprocesses and experimental design (DoE)
- Expertise with quantitative determination of scalable process parameters for normal flow filtrations, tangential flow filtrations, and preparative chromatographic separations
- Knowledge of cGMP manufacturing operations and GxP principles
- Experience with protein bioanalytical techniques (HPLC, LC-MS, CE-SDS, UV-spectrophotometry, etc.)
- Experience with large scale bioprocess equipment (pallet tanks, pumps, biowelders, biosealers, bio-rockers, single-use assemblies)
- Prior leadership experience
- Travel between Abzena sites (Bristol PA, San Diego CA, Cambridge UK) as needed
- Ability to stand for 1-2 hours at a time, sit for 2 to 3 hours at a time
- Frequently lift and or move objects up to 30 pounds
- Ability to climb, balance, stoop, kneel, crouch, or crawl
- Visual abilities including near and far sight, color, peripheral vision, depth and ability to focus
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