Associate Director or Director, PBPK & Biopharmaceutics Modeling
$160,000–$275,000 year
On-siteWatertown, Massachusetts, United States
Job Summary
Lead and grow Kymera's PBPK/PBBM capability by defining workflows, standards, best practices, and software strategy. Apply translational PBPK/PBBM to predict human PK and oral bioavailability across species, formulations, and dose levels, supporting first-in-human dose selection. Partner with CMC to support formulation selection and optimization through PBBM, while developing IVIVC and mechanistic in vitro-in vivo dissolution models to link drug product performance to in vivo behavior. Apply PBPK to clinical pharmacology questions such as drug-drug interactions, food effects, and special populations to inform clinical study design and dose adjustments. Embed within multidisciplinary project teams to provide real-time study-design support and rapid model iteration as new data emerge, liaising with collaboration partners and CROs to generate data and analyses. Represent the DMPK perspective on project teams and prepare reports to support regulatory submissions and respond independently to health authority questions.
Required Qualifications
- PhD or PharmD (or equivalent) in pharmaceutical sciences, DMPK, pharmacokinetics, chemical/biomedical engineering, or a related field
- 7+ years of hands-on PBPK/PBBM experience
- Deep understanding of ADME/DMPK and biopharmaceutics principles
- Significant hands-on GastroPlus experience
- Demonstrated ability to manage and deliver modeling work independently
- Proven ability to build mechanistic absorption and whole-body PBPK models
- Translate preclinical data into human PK predictions for oral small molecules
- Deliver practical, timely, and impactful recommendations to advance programs
- Experience modeling oral molecules with challenging developability profiles, including poorly soluble and/or permeable compounds and beyond-rule-of-five modalities
- Proficiency in scripting for data handling, workflow automation, and model QC (e.g., R, Python, or MATLAB)
- Demonstrated ability to work collaboratively with cross-functional teams in a fast-paced environment with changing priorities
- Ability to communicate clearly and concisely with specialist and non-specialist stakeholders, including leadership and project management
Desired Qualifications
- Experience modeling oral molecules with challenging developability profiles, including poorly soluble and/or permeable compounds and beyond-rule-of-five modalities such as targeted protein degraders
- Simcyp modeling experience
- Track record of PBPK/PBBM contributions to regulatory submissions such as IND, NDA, DDI, or biopharmaceutics packages
- DMPK project representative experience
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