Associate Director/Director, Protein Sciences
$180,000–$240,000 year
On-siteBothell, Washington, United States
Job Summary
Lead the Protein Sciences group, managing hiring, mentoring, and performance of scientists while serving as the subject-matter expert on cross-functional oncology biologics programs. Drive end-to-end protein production workflows, including construct design, mammalian expression (HEK293, CHO), and purification of complex membrane proteins and multi-specific antibodies. Establish biochemical and biophysical characterization capabilities to confirm identity, purity, and stability, and design automation workflows to increase departmental capacity. Partner with Protein Engineering, Antibody Discovery, and external teams to advance molecules from discovery through IND-enabling activities. This full-time onsite role at SystImmune's Bothell, WA location requires deep expertise in protein engineering and biophysical characterization to deliver high-quality reagents on program timelines.
Required Qualifications
- Ph.D. in biochemistry, protein chemistry, molecular biology, bioengineering, or a related field
- M.S. or B.S. with commensurate additional experience
- 8+ years (Director) or 6+ years (Associate Director) of relevant industry experience in biologics discovery and development
- 3+ years of people-management experience leading scientists in a protein sciences, protein production, or biologics discovery setting
- Deep hands-on expertise in mammalian expression systems and multi-modal antibody purification (Protein A/L, ion exchange, HIC, SEC, mixed-mode)
- Demonstrated experience producing and characterizing complex biologics, including: Membrane proteins, Dimer and heterodimer complexes, Engineered molecules for proving PPI and antibody binding sites
- Strong working knowledge of biophysical characterization techniques and data interpretation (SPR/BLI, SEC-MALS, DSF/DSC, mass spectrometry, capillary electrophoresis)
- Proven track record of advancing molecules from discovery through candidate selection and supporting IND-enabling activities
- Excellent scientific judgment, communication, and cross-functional collaboration skills, with the ability to operate effectively in a fast-paced, milestone-driven environment
- Full-time onsite at Bothell, WA location
- May need to work outside of standard working hours at times
Desired Qualifications
- Familiarity with high-throughput automation platforms (liquid handlers, parallel purification systems) and structured data capture (ELN/LIMS)
- Experience in oncology biologics and understanding of tumor-targeting antibody design principles
- Mandarin-English Bilingual Ability
- Prior contribution to regulatory filings (IND/IMPD) and interactions with process development or quality organizations
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