Associate Director, Affinity Reagent Development and Characterization
$164,000–$221,000 year
On-site · San Carlos, California, United States
Job Summary
Associate Director, Affinity Reagent Development and Characterization leads and mentors a team spanning affinity reagent discovery through molecular characterization, directing strategies for library panning, antibody production, and affinity maturation. The role emphasizes in-silico design and ML/AI-driven methods to advance affinity reagents, ensures rigorous data-driven progress across timelines from weeks to years, and collaborates across assay development, engineering, biochemistry, and software to optimize the Nautilus platform. Responsibilities include guiding strategy, evaluating probe targets, managing external vendors, and delivering measurable scientific progress while upholding high standards of rigor and collaboration. The ideal candidate combines hands-on expertise with leadership to drive the affinity reagent pipeline and characterize binding interactions to enable robust single-molecule proteomics assays.
Required Qualifications
- PhD in biophysics, protein chemistry, structural biology, or similar field + 10 years experience (or postdoc + 5 years experience)
- 5+ years of management experience
- Demonstrated hands-on experience with affinity reagents, especially antibodies, including library panning (e.g. phase and/or ribosome-display) and affinity maturation
- Demonstrated experience using in silico and ML/AI tools to investigate and optimize affinity reagents
- Experience with interaction characterization tools such as SPR and BLI and high throughput protein-protein interaction / reactome characterization tools
- Exceptional communication, collaboration, and presentation skills
- Strong leadership, strategic planning, and decision-making capabilities
- Preferred: Experience leading fast paced discovery teams
- Preferred: Background in launching products
- Preferred: Experience with a variety of antibody discovery libraries
- Preferred: Experience incorporating novel affinity reagents and antibodies into bioassays
Desired Qualifications
- PhD in biophysics, protein chemistry, structural biology, or similar field
- 10 years experience (or postdoc + 5 years)
- 5+ years of management experience
- Hands-on experience with affinity reagents, especially antibodies, including library panning and affinity maturation
- Experience using in silico and ML/AI tools for affinity reagent optimization
- Experience with interaction characterization tools such as SPR and BLI
- High-throughput protein-protein interaction / reactome characterization tools
- Exceptional communication, collaboration, and presentation skills
- Strong leadership, strategic planning, and decision-making capabilities
- Experience leading fast paced discovery teams
- Background in launching products
- Experience with antibody discovery libraries
- Experience integrating novel affinity reagents into bioassays
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