Analytical Scientist
$135,000–$155,000 year
On-siteEmeryville, California, United States
Job Summary
Develop and implement high-throughput DMPK assays suitable for ML methods, while identifying, developing, and deploying chromatographic and mass spectrometric methodologies to analyze small molecules. Design, optimize, and troubleshoot LC-MS/MS and UHPLC methods from first principles, including sample preparation and data interpretation across complex biological matrices. Analyze and develop methods to interpret complex analytical data using R, Python, and other computational tools, presenting findings to internal and external project teams. Work hand-in-hand with machine learning scientists, software engineers, biologists, chemists, and automation engineers to expand the Octant Navigator platform for generating ADMET datasets.
Required Qualifications
- PhD in Analytical Chemistry, Biochemistry, Chemistry, Chemical Biology or a related discipline
- 3-5 years of post-PhD experience in analytical/bioanalytical research
- Deep technical expertise with analytical instrumentation including, but not limited to, HPLC, UPLC, LC-MS, CAD/MS, EchoMS, and various spectroscopic techniques
- Hands-on chromatographic method development experience across multiple modes — reversed-phase, normal-phase, HILIC, SEC, SFC, and 2D-LC/MS
- Strong familiarity with DMPK and its role in small molecule drug discovery
- Experience with chromatography and/or MS data systems (e.g., SciexOS, Xcalibur, MassHunter, Chromeleon, Virscidian, Skyline)
- Strong computational skills including familiarity with R, python, command-line interfaces and/or statistical analysis
- Experience with laboratory automation platforms and high-throughput screening methods
- Flexibility to rapidly changing priorities and project needs, with the ability to thrive in a fast-paced, collaborative environment
- Comfortable with ambiguity and able to pivot strategies as needed to meet project goals
- Strong problem-solving and decision-making abilities, with a proactive approach to anticipating potential issues and addressing them before they become critical
- A drive to build a successful company in your role as an analytical scientist and beyond
- Industry experience preferred
Desired Qualifications
- Industry experience preferred
- Experience with BBB assay development
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